منابع مشابه
Interleukin signaling
Interleukins are low molecular weight proteins produced by leukocytes that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. These secreted factors modify the cell differentiation program (survival, proliferation, maturation, induction of or protection from apoptosis) of the target cells to which they bind. As such, interleukins impact on diverse biological proces...
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Diabetic kidney disease is characterized by increased albuminuria associated with structural changes, such as thickening of the glomerular basement membrane, mesangial expansion, and podocyte depletion followed by glomerulosclerosis. Glomerulosclerosis is preceded by early hypertrophic changes in the glomerulus [1]. Among the many characteristic glomerular pathologic changes, a decrease in the ...
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The murine T lymphoma line, LBRM-33 1A5, requires synergistic signals delivered by phytohemagglutinin (PHA) and interleukin 1 (IL1) for activation to high level interleukin 2 production. The activation signals provided by PHA and IL1 were replaced by the Ca2+ ionophore, ionomycin, and the phorbol ester, 120-tetradecanoylphorbol 13-acetate (TPA), respectively. These observations upported a ...
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Interleukin-6 (IL-6) is a multifunctional cytokine with important functions in various physiologic processes. Mice lacking IL-6 exhibit multiple phenotypic abnormalities, such as an inadequate immune and acute-phase response, and elevated levels of circulating IL-6 have been found to accompany several pathological conditions. IL-6 binds the nonsignaling IL-6 receptor (IL-6R), which is expressed...
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Three forms of interleukin-6 (IL-6) have been constructed and stably transfected into human hepatoma cells (HepG2). Wild type IL-6 containing a signal peptide was rapidly secreted as a biologically active protein. IL-6 lacking the signal peptide accumulated within the cytoplasm of transfected cells. Surprisingly, IL-6 carrying a COOH-terminal extension of the amino acids Lys-Asp-Glu-Leu (KDEL) ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2002
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(02)01286-1